Peyronie's Disease Treatment in Lake Mary, Florida (FL)

After your Peyronie’s disease diagnosis, your doctor may recommend waiting a year to see if the condition resolves itself non-surgically. If your doctor determines that more intervention is necessary, Peyronie’s disease may be treated with medication taken orally or injected into the penis. Your Urologist may consider surgical treatment options if time and medication prove ineffective. Because Peyronie’s disease is not fully understood, many treatments for the condition are considered experimental.

Nonsurgical Treatments for Peyronie's Disease

Medication for Peyronie’s disease can be administered orally or by injection.

Oral medications are still experimental in their use. Tamoxifen is an anti-estrogen, anti-inflammatory medication which researchers suggest may help reduce pain, plaque size, and penile curvature. Colchicine and carnitine are also anti-inflammatories which may have the ability to break apart hard plaque and thus alleviate symptoms. No placebo-controlled studies have been performed to determine the effectiveness of either Tamoxifen or Colchicine/carnitine.

Some smaller studies suggest that Vitamin E may reduce pain and penile curvature. Other smaller studies point to the usefulness of Potaba (potassium amino-benzoate) in reducing pain and penile plaque, but not penile curvature.

Injectable medication for Peyronie’s disease may allow higher doses to be administered with more local effects than oral medications. These may include Verapamil, a calcium channel blocker that is typically used in the treatment of high blood pressure. Verapamil disrupts collagen production and for this reason is used in the treatment of Peyrionie's disease. Several uncontrolled studies suggest that it reduced penile pain and curvature, but no large-scale placebo-controlled studies are available to confirm verapamil’s effectiveness.

In one large placebo controlled study, Interferon alpha-2b was injected directly into the scar tissue of the penis. Some men experienced relief from pain, penile curvature, and sexual function after receiving interferon injections. In one small study, men experienced some relief after receiving injections of the enzyme Collagenase into the penile plaque site. Researchers are looking forward to the results of a larger study currently underway.

Surgical Treatments for Peyronie's Disease

If time and medication are not effective in alleviating your symptoms, your doctor may recommend surgical options.

Grafting may effectively alleviate the symptoms of Peyronie’s by removing plaque on the penis and replacing it with healthy skin taken from another location on the body. Another surgical option for treating Peyronie’s disease is the Nesbit procedure in which the doctor slices the around the plaque, pulls the skin down to expose the underlying tissue, and then straitens the penis. Excess tissue is then removed or cinched together. Another procedure which may help treat Peyronie’s is implanting a prosthetic penile device to improve rigidity and straiten the penis.

Discuss treatment for Peyronie’s disease with your doctor to determine the best options for you.


About Charles N. Witten, MD

Dr. Witten received his B.A. in Biology from the University of Pennsylvania in Philadelphia, Pennsylvania in 1980. He subsequently completed his medical education at the University of Pittsburgh School of Medicine in 1984. He returned to Philadelphia to complete his General Surgical and Urological Surgery Residencies at the Hospital of the University of Pennsylvania from 1984 - 1990. The University of Pennsylvania's Urological Surgery Residency is considered on of the top training programs in the country. He served as chief resident his final year. Dr. Witten joined Central Florida Urology Associates after completing his residency in 1990. He has been board-certified by The American Board of Urology since 1992.

Dr. Witten has served on numerous hospital committees including chairmanships of surgical peer review and credentials committees. He has served on the Education Committee for the Seminole County Medical Society. From 2002-2005, he served as Chairman of the Department of Urology at Florida. During his tenure, the hospital procured the DaVinci Robot to perform robotic assisted laparoscopic surgery. Dr. Witten's particular areas of interest include prostate, bladder and renal cancers; urinary incontinence; erectile dysfunction with emphasis on penile implant surgery; male infertility; microscopic surgery including vasectomy reversal; DaVinci robotic radical prostatectomy; laparoscopic urological surgery, and management of Benign Prostatic Hyperplasia with minimally invasive techniques including microwave thermotherapy and green light laser Photo-vaporization (PVP) of the prostate.

Dr. Witten is an active member of The American Urological Society, The American Association of Clinical Urologist, The American Fertility Society, The Florida Urological Society and The Seminole County Medical Society. He is married with four children and resides in Lake Mary, Florida.

Featured Specialist for Peyronie's Disease Treatment in Lake Mary, FL

Charles N. Witten, MD

Call Now: (407) 287-5443
210 Rinehart Road
Suite 1000
Lake Mary, FL 32746

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